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Risk factors for depression in elderly persons include a family history of depression; chronic medical illness; use of certain medications; female gender; . patient Mirtazapine is generally considered a second-line agent Elderly patients should be initiated at lower dosages and titrated more slowly. Hyponatremia has been reported very rarely with the use of mirtazapine. Caution should be exercised in patients at risk, such as elderly patients or patients concomitantly treated with medications known to cause hyponatremia.

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