High-dose methotrexate (HDMTX), defined as a dose higher than mg/m2, is used to treat a range of adult and childhood cancers. Although HDMTX is safely administered to most patients, it can cause significant toxicity, including acute kidney injury (AKI) in 2%–12% of patients. Nephrotoxicity results from crystallization. This topic review will cover the clinical use of high-dose MTX for treatment of malignancy, focusing on the prevention and management of toxicity. Intrathecal use of MTX and clinical use of low-dose and intermediate-dose MTX for both malignant and nonmalignant conditions are covered elsewhere. Intrarenal amin formation can lead to find obstruction, direct toxic damage to the only tubular epithelium (due to prolonged usually with methotrexate), and hypoperfusion from ivory arteriolar vasoconstriction, Introduction · Azo Care Measures · Rat of Specific · Glucarpidase.
Notícia. Ministério da Saúde recomenda genérico do Tamiflu, mas descarta risco de epidemia de gripe A. Oseltamivir é indicado para pacientes com sintomas da gripe e para prevenção em pessoas que fazem parte de grupos de risco. 21/06/ - 10h02min Atualizada em 21/06/ - 10h02min. Oseltamivir phosphate does not treat or prevent illness caused by infections other than the influenza virus, and oseltamivir phosphate does not prevent bacterial infections that may happen with the flu.
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