Digoxin caco-2

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Phytother Res. Dec;22(12) doi: /ptr Caco-2 cell methodology and inhibition of the P-glycoprotein transport of digoxin by Aloe vera juice. Djuv A(1), Nilsen OG. Author information: (1)Norwegian University of Science and Technology, Faculty of Medicine, Department of Cancer Research and. Modulation of digoxin transport across Caco-2 cell monolayers by citrus fruit juices: lime, lemon, grapefruit, and pummelo. Xu J(1), Go ML, Lim LY. Author information: (1)Department of Pharmacy, National University of Singapore 18 Science Drive 4, Singapore PURPOSE: To evaluate the effects of fresh lime, lemon.

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Eur J Pharm Sci. Dec;26(5) Epub Sep 8. Comparison of P-glycoprotein-mediated drug-digoxin interactions in Caco-2 with human and rodent intestine: relevance to in vivo prediction. Collett A(1), Tanianis-Hughes J, Carlson GL, Harwood MD, Warhurst G. Author information: (1)University of Manchester. Purpose. To evaluate the effects of fresh lime, lemon, grapefruit, and pummelo juices on the transport of digoxin, a P-glycoprotein (P-gp) substrate, in Caco-2 cell monolayers. Methods. Bidirectional [3H]-digoxin fluxes across confluent Caco-2 cell monolayers were determined in 0–50% fruit juices at pH Verapamil HCl.

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LY Digoxin caco-2 Barrio of 3H-digoxin through Caco-2 vibrance in the presence of PGP inhibitors. (Verapamil digoxin caco-2 μM, GF and LY 1 μM, PSC 10 μM). PAPP in -6 cm/s. A-B. B-A. Sine 2: Flux of 3H-digoxin through Caco-2 leak in the presence of verapamil, GF, LY and PSC Secondly, IC50 measurements using digoxin caco-2 as a medication substrate in this cell cancer could be due to work of P-gp, of digoxin product transport, or both. That kinetic analysis is now extended to induce three additional cell lines: MDCK-MDR1-NIH (Catheter Institute of Euphoria), Caco-2 and CPT-B2 (Caco.

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